Across TCGA patient cohorts, H3C12 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C12-associated genes across cancer lineages are ERK2, FOXO3a_pS318_S321, and INPP4B. Each is linked with H3C12 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C12-to-partner and partner-to-H3C12 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C12→partner) and Y-score (partner→H3C12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.300	+3.584	.001	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.153	-2.459	.011	.020	3	1
UCEC	INPP4B →	-0.361	-3.000	.020	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-2.446	.003	.020	3	1
UCEC	Ku80 →	+0.235	+3.598	.039	.001	3	1
UCEC	MEK1 →	+0.529	+3.584	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

H3C12 survival (RNA) · tumor vs normal (RNA) · all H3C12 data types