H3C11

Across TCGA patient cohorts, H3C11 mutation is significantly associated with the RNA expression of many other genes, with 760 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C11-associated genes across cancer lineages are RN7SL346P, KRTAP9-10P, and MIR151A. Each is linked with H3C11 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C11-to-partner and partner-to-H3C11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL346P grouped by H3C11-low versus H3C11-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C11→partner) and Y-score (partner→H3C11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL346P →	+0.164	+3.716	.001	.008	3	2
BRCA	KRTAP9-10P →	+0.158	+8.471	<.001	.005	3	2
BLCA	MIR151A →	+0.307	+4.266	.001	.003	3	2
UCEC	RNA5SP516 →	+0.265	+3.352	<.001	.004	3	2
UCEC	MIR188 →	+0.212	+3.997	.002	.001	3	2
COAD	TRAJ5 →	+1.109	+3.364	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 760 associations by consensus.

RN7SL346P by H3C11 expression — HNSC

Explore this box plot interactively →