H3C11

Across TCGA patient cohorts, H3C11 mutation is significantly associated with the immune_cell of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H3C11-associated genes across cancer lineages are iDC, CD4+ Tem, and CD4+ Tcm. Each is linked with H3C11 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C11-to-partner and partner-to-H3C11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, iDC grouped by H3C11-low versus H3C11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C11→partner) and Y-score (partner→H3C11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	iDC →	+0.177	+2.321	.034	.036	3	2
BRCA	CD4+ Tem →	+0.021	+6.234	<.001	.026	3	1
COAD	CD4+ Tcm →	+0.010	+5.156	<.001	.032	3	1
UCEC	CD8+ T-cells →	+0.029	+2.845	<.001	.005	3	1
UCEC	CD8+ Tcm →	+0.043	+2.350	<.001	.031	3	1
UCEC	CD8+ Tem →	+0.003	+4.606	<.001	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

iDC by H3C11 expression — UCEC

Explore this box plot interactively →