H3C1

Across TCGA pan-cancer cohorts, H3C1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H3C1 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher H3C1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated H3C1 expression acts as an unfavorable survival marker.

LUSC, COAD, and ACC are the cancer types where H3C1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	9	view →
COAD	OS	Median	All	0.113	0.806	<.001	6	view →
ACC	OS	Median	All	0.118	0.624	.038	6	view →
LUAD	OS	Median	All	0.241	0.684	.037	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H3C1–LUSC (DFS)

Open the LUSC breakdown →