H3C1

Across TCGA patient cohorts, H3C1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible H3C1-associated genes across cancer lineages are OR4X2, RBMY1HP, and RNU6-452P. Each is linked with H3C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C1-to-partner and partner-to-H3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by H3C1-low versus H3C1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C1→partner) and Y-score (partner→H3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR4X2 →	+0.054	+7.741	<.001	.009	3	2
SKCM	RBMY1HP →	+0.039	+7.816	<.001	.008	3	1
SKCM	RNU6-452P →	+0.868	+7.816	<.001	.008	3	1
COAD	RNU6-764P →	+0.382	+7.741	<.001	.009	3	1
COAD	MIR3171 →	+0.793	+7.741	<.001	.009	3	1
LUSC	RNU6-1090P →	+0.422	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OR4X2 by H3C1 expression — COAD

Explore this box plot interactively →