H3C1

Across TCGA cell cohorts, H3C1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,409 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H3C1-associated GO terms across cancer lineages are Positive regulation of protein localization to chromatin, Regulation of protein localization to chromatin, and Protein acetylation. Each is linked with H3C1 in more than 7 cancer types. Because this analysis shows association rather than direction, both H3C1-to-partner and partner-to-H3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to chromatin grouped by H3C1-low versus H3C1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C1→partner) and Y-score (partner→H3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of protein localization to chromatin →	+0.107	+0.353	<.001	.002	3	8
PANCREAS	Regulation of protein localization to chromatin →	+0.070	+0.407	<.001	<.001	3	8
OVARY	Protein acetylation →	+0.057	+0.397	.009	.008	3	7
PANCREAS	Mitotic chromosome condensation →	+0.086	+0.363	.004	<.001	3	7
PANCREAS	Positive regulation of DNA-templated DNA replication →	+0.109	+0.505	<.001	<.001	3	7
PANCREAS	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.108	+0.433	.002	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,409 associations by consensus.

Positive regulation of protein localization to chromatin by H3C1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →