H3C1

Across TCGA cell cohorts, H3C1 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible H3C1-associated genes across cancer lineages are GPR42 and CXorf51A. Each is linked with H3C1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H3C1-to-partner and partner-to-H3C1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GPR42 grouped by H3C1-low versus H3C1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H3C1→partner) and Y-score (partner→H3C1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR42 →	+0.016	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	CXorf51A →	+0.048	+4.887	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

GPR42 by H3C1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →