H3-3A

Across TCGA pan-cancer cohorts, H3-3A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H3-3A data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher H3-3A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H3-3A expression acts as an unfavorable survival marker.

CESC, LUSC, and DLBC are the cancer types where H3-3A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.095	0.755	<.001	42	view →
LUSC	OS	Median	All	0.080	0.762	<.001	24	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
LGG	OS	Median	All	0.244	0.801	<.001	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H3-3A–CESC (OS)

Open the CESC breakdown →