H3-2

Across TCGA pan-cancer cohorts, H3-2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H3-2 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H3-2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated H3-2 expression acts as an unfavorable survival marker, although some lineages such as COAD and CCRCC show a favorable association.

COAD, CCRCC, and PDAC are the cancer types where H3-2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.919	.013	24	view →
CCRCC	OS	Median	All	0.948	0.752	.002	19	view →
PDAC	OS	Median	III,IV	0.231	0.475	.028	9	view →
HNSC	OS	Quartile	IV	1.000	0.828	.019	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H3-2–COAD (DFS)

Open the COAD breakdown →