H2BW3P

Across TCGA pan-cancer cohorts, H2BW3P RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of H2BW3P’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where H2BW3P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BW3P is over-expressed in tumor, although a few such as BRCA and PRAD show the opposite, repressed pattern.

KIRC, BRCA, and HNSC are the cancer types where H2BW3P tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BW3P RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.251	<.001	12	view →
BRCA	All	III,IV	−0.301	<.001	6	view →
HNSC	Male	III,IV	+0.120	.011	5	view →
ESCA	All	All	+0.341	.008	4	view →
CHOL	Male	All	+0.455	.001	2	view →
PRAD	All	All	−0.172	<.001	2	view →
BLCA	Male	IV	−0.362	.015	1	view →
KIRP	All	All	+0.191	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

H2BW3P–KIRC

Open the KIRC breakdown →