H2BW1

Across TCGA pan-cancer cohorts, H2BW1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated H2BW1 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher H2BW1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2BW1 expression acts as an unfavorable survival marker.

ESCA and SKCM are the cancer types where H2BW1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.080	0.701	<.001	12	view →
SKCM	OS	Median	III,IV	0.179	0.721	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

H2BW1–ESCA (OS)

Open the ESCA breakdown →