Across TCGA pan-cancer cohorts, H2BP6 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of H2BP6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2BP6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2BP6 is over-expressed in tumor, although a few such as BRCA and LUAD show the opposite, repressed pattern.

HNSC, BRCA, and CHOL are the cancer types where H2BP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2BP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	+0.146	.006	3	view →
BRCA	All	All	−0.075	.006	3	view →
CHOL	Male	All	+0.291	.002	2	view →
LUAD	Female	All	−0.211	.001	2	view →
THCA	All	All	−0.062	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: H2BP6 RNA expression & survival · all H2BP6 data types