H2BP2

Across TCGA patient cohorts, H2BP2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BP2-associated genes across cancer lineages are VHL, IRS1, and Notch1. Each is linked with H2BP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BP2-to-partner and partner-to-H2BP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by H2BP2-low versus H2BP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BP2→partner) and Y-score (partner→H2BP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.938	-3.000	.016	.037	3	1
UCEC	IRS1 →	+0.369	+3.000	.002	.037	2	1
UCEC	Notch1 →	+0.249	+3.000	.002	.037	2	1
UCEC	Rab25 →	-0.554	-3.000	.003	.037	2	1
UCEC	p27_pT198 →	+0.133	+3.000	.031	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

VHL by H2BP2 expression — UCEC

Explore this box plot interactively →