H2BC6

Across TCGA patient cohorts, H2BC6 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible H2BC6-associated genes across cancer lineages are AK6P1, RN7SL468P, and MTHFD2P5. Each is linked with H2BC6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC6-to-partner and partner-to-H2BC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AK6P1 grouped by H2BC6-low versus H2BC6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC6→partner) and Y-score (partner→H2BC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AK6P1 →	+0.370	+3.718	.004	.006	3	2
BLCA	RN7SL468P →	+0.199	+5.618	<.001	.002	3	2
BLCA	MTHFD2P5 →	+0.064	+5.376	<.001	.001	3	2
BLCA	ARMC8P1 →	+0.038	+4.799	.001	.003	3	2
BLCA	SNORD116-25 →	+0.339	+5.289	<.001	.003	3	2
SKCM	GUSBP12 →	+0.325	+5.097	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

AK6P1 by H2BC6 expression — UCEC

Explore this box plot interactively →