H2BC6

Across TCGA cell cohorts, H2BC6 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,063 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H2BC6-associated GO terms across cancer lineages are Positive regulation of ubiquitin-dependent protein catabolic process, Positive regulation of proteasomal ubiquitin-dependent protein catabolic process, and Locomotor rhythm. Each is linked with H2BC6 in more than 6 cancer types. Because this analysis shows association rather than direction, both H2BC6-to-partner and partner-to-H2BC6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of ubiquitin-dependent protein catabolic process grouped by H2BC6-low versus H2BC6-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC6→partner) and Y-score (partner→H2BC6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Positive regulation of ubiquitin-dependent protein catabolic process →	+0.055	+0.587	.002	.005	2	7
STOMACH	Positive regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.067	+0.600	.003	.004	3	6
KIDNEY	Locomotor rhythm →	+0.155	+0.379	<.001	.004	3	6
OVARY	Spliceosomal tri-snRNP complex assembly →	+0.089	+0.458	<.001	.002	3	6
OVARY	Regulation of RNA splicing →	+0.069	+0.667	<.001	<.001	3	6
BREAST	Regulation of Golgi organization →	+0.059	+0.746	.004	.005	1	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,063 associations by consensus.

Positive regulation of ubiquitin-dependent protein catabolic process by H2BC6 expression — STOMACH

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