H2BC5

Across TCGA patient cohorts, H2BC5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,496 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible H2BC5-associated genes across cancer lineages are LCA5, NUDT8, and UPP2. Each is linked with H2BC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC5-to-partner and partner-to-H2BC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H2BC5 versus LCA5 in LUAD, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC5→partner) and Y-score (partner→H2BC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LCA5 →	+0.992	+0.581	.001	.002	3	2
BRCA	NUDT8 →	-0.892	-0.355	.001	.005	3	2
LUAD	UPP2 →	+0.405	+0.399	.004	.005	3	2
OV	CRBN →	+0.663	+0.704	<.001	.002	3	2
BRCA	CLK1 →	+0.626	+0.543	<.001	<.001	3	2
OV	SSBP2 →	+0.746	+0.681	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,496 associations by consensus.

H2BC5 vs LCA5 — LUAD

Explore this scatter interactively →