H2BC4

Across TCGA pan-cancer cohorts, H2BC4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H2BC4 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher H2BC4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2BC4 expression acts as an unfavorable survival marker.

DLBC, CESC, and UCEC are the cancer types where H2BC4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	All	0.037	0.848	<.001	21	view →
CESC	DFS	Median	II,III,IV	0.146	0.705	.010	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

H2BC4–DLBC (DFS)

Open the DLBC breakdown →