H2BC4

Across TCGA patient cohorts, H2BC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,297 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible H2BC4-associated proteins across cancer lineages are SMC2, MAD2L1, and NCAPH. Each is linked with H2BC4 in more than 7 cancer types. Because this analysis shows association rather than direction, both H2BC4-to-partner and partner-to-H2BC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H2BC4 versus SMC2 in GBM, with a Pearson correlation of 0.71.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC4→partner) and Y-score (partner→H2BC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.717	+0.922	<.001	<.001	3	8
GBM	MAD2L1 →	+0.571	+0.619	<.001	<.001	3	7
GBM	NCAPH →	+0.739	+0.919	<.001	<.001	3	7
GBM	POLE3 →	+0.396	+0.502	<.001	<.001	3	7
LUAD	RBBP5_S497 →	+0.877	+0.519	<.001	<.001	3	7
LSCC	UBTF_S484 →	+0.880	+0.547	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,297 associations by consensus.

H2BC4 vs SMC2 — GBM

Explore this scatter interactively →