H2BC4

Across TCGA patient cohorts, H2BC4 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible H2BC4-associated genes across cancer lineages are Pericytes, Fibroblasts, and pDC. Each is linked with H2BC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC4-to-partner and partner-to-H2BC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Pericytes grouped by H2BC4-low versus H2BC4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC4→partner) and Y-score (partner→H2BC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Pericytes →	+0.043	+2.754	.006	.026	3	1
HNSC	Fibroblasts →	+0.012	+5.339	.044	.047	3	1
UCEC	pDC →	+0.094	+2.839	<.001	.034	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Pericytes by H2BC4 expression — LUAD

Explore this box plot interactively →