H2BC4

Across TCGA cell cohorts, H2BC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,527 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H2BC4-associated GO terms across cancer lineages are Establishment of protein localization to membrane, Vacuole organization, and Macroautophagy. Each is linked with H2BC4 in more than 9 cancer types. Because this analysis shows association rather than direction, both H2BC4-to-partner and partner-to-H2BC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Establishment of protein localization to membrane grouped by H2BC4-low versus H2BC4-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC4→partner) and Y-score (partner→H2BC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Establishment of protein localization to membrane →	+0.041	+1.255	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Vacuole organization →	+0.046	+1.333	<.001	<.001	3	10
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.062	+1.036	<.001	.003	3	10
CNS	Protein localization to CENP-A containing chromatin →	+0.383	+1.181	.006	<.001	3	9
UPPER_AERODIGESTIVE_TRACT	Process utilizing autophagic mechanism →	+0.058	+1.088	<.001	.001	3	9
UPPER_AERODIGESTIVE_TRACT	Autophagy →	+0.058	+1.088	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,527 associations by consensus.

Establishment of protein localization to membrane by H2BC4 expression — OVARY

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