H2BC3

Across TCGA pan-cancer cohorts, H2BC3 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H2BC3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher H2BC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2BC3 expression acts as an unfavorable survival marker.

COAD, THYM, and HNSC are the cancer types where H2BC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	II,III,IV	0.201	0.792	<.001	24	view →
THYM	OS	Median	All	0.186	0.931	<.001	15	view →
HNSC	OS	Median	All	0.195	0.714	<.001	9	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H2BC3–COAD (OS)

Open the COAD breakdown →