Across TCGA pan-cancer cohorts, H2BC18 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated H2BC18 data layer compared with 3 for mutation status.
The strongest signal is observed in colon adenocarcinoma (COAD), where higher H2BC18 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated H2BC18 expression acts as an unfavorable survival marker, although some lineages such as SCLC and LIHC show a favorable association.
COAD, KIRP, and UVM are the cancer types where H2BC18 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.