H2BC17

Across TCGA patient cohorts, H2BC17 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC17-associated genes across cancer lineages are RNU6-40P, RNU6-73P, and RNU6-1104P. Each is linked with H2BC17 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC17-to-partner and partner-to-H2BC17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-40P grouped by H2BC17-low versus H2BC17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC17→partner) and Y-score (partner→H2BC17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-40P →	+0.448	+4.551	<.001	.009	3	1
UCEC	RNU6-73P →	+0.382	+5.226	<.001	.003	3	1
UCEC	RNU6-1104P →	+0.700	+4.852	<.001	.006	3	1
UCEC	IGHD1-26 →	+1.308	+4.484	<.001	.009	3	1
UCEC	FAT1P1 →	+0.151	+5.582	.001	.002	3	1
UCEC	RPL36AP53 →	+0.264	+4.233	.003	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RNU6-40P by H2BC17 expression — UCEC

Explore this box plot interactively →