H2BC15

Across TCGA patient cohorts, H2BC15 mutation is significantly associated with the RNA expression of many other genes, with 749 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC15-associated genes across cancer lineages are RNA5SP519, LINC01256, and RBM17P3. Each is linked with H2BC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC15-to-partner and partner-to-H2BC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP519 grouped by H2BC15-low versus H2BC15-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC15→partner) and Y-score (partner→H2BC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP519 →	+0.638	+5.093	<.001	.008	3	2
BLCA	LINC01256 →	+0.065	+4.788	.004	.006	3	2
COAD	RBM17P3 →	+0.059	+7.741	<.001	.009	3	2
HNSC	RNU6ATAC22P →	+0.308	+4.754	<.001	.005	3	2
HNSC	MIR4752 →	+0.291	+5.351	<.001	.002	3	2
BLCA	USP29 →	+0.014	+4.268	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 749 associations by consensus.

RNA5SP519 by H2BC15 expression — LUSC

Explore this box plot interactively →