H2BC14

Across TCGA patient cohorts, H2BC14 mutation is significantly associated with the RNA expression of many other genes, with 247 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2BC14-associated genes across cancer lineages are RPL23AP4, RNU6-893P, and SNORA24B. Each is linked with H2BC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC14-to-partner and partner-to-H2BC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP4 grouped by H2BC14-low versus H2BC14-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC14→partner) and Y-score (partner→H2BC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	RPL23AP4 →	+0.182	+5.624	<.001	<.001	3	2
READ	RNU6-893P →	+0.646	+4.445	<.001	.005	3	2
UCEC	SNORA24B →	+0.516	+2.354	<.001	.006	3	2
UCEC	RNU6-1245P →	+0.459	+3.081	<.001	.002	3	2
UCEC	RNU6-1054P →	+0.343	+2.591	.006	.004	3	2
UCEC	LINC01689 →	+0.055	+2.352	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 247 associations by consensus.

RPL23AP4 by H2BC14 expression — READ

Explore this box plot interactively →