H2BC11

Across TCGA cell cohorts, H2BC11 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible H2BC11-associated genes across cancer lineages are P2RX3, FABP12, and SPATA31A7. Each is linked with H2BC11 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC11-to-partner and partner-to-H2BC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P2RX3 grouped by H2BC11-low versus H2BC11-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC11→partner) and Y-score (partner→H2BC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	P2RX3 →	+0.077	+4.025	<.001	.004	3	1
BLOOD_Lymphoma	FABP12 →	+0.035	+4.058	.001	.009	3	1
BLOOD_Lymphoma	SPATA31A7 →	+0.051	+3.523	<.001	.009	3	1
CNS	IFNG →	+0.078	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

P2RX3 by H2BC11 expression — BLOOD_Lymphoma

Explore this box plot interactively →