H2BC10

Across TCGA patient cohorts, H2BC10 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible H2BC10-associated genes across cancer lineages are MIR6737, RN7SKP104, and RNU6-99P. Each is linked with H2BC10 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2BC10-to-partner and partner-to-H2BC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6737 grouped by H2BC10-low versus H2BC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2BC10→partner) and Y-score (partner→H2BC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6737 →	+0.982	+5.299	<.001	.006	3	2
SKCM	RN7SKP104 →	+0.099	+7.816	<.001	.008	3	1
SKCM	RNU6-99P →	+0.463	+7.816	<.001	.008	3	1
UCEC	RNA5SP426 →	+0.710	+6.453	<.001	.001	3	1
UCEC	MIR520H →	+0.882	+6.582	<.001	.001	3	1
UCEC	MIR204 →	+0.602	+5.694	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

MIR6737 by H2BC10 expression — UCEC

Explore this box plot interactively →