H2AZP4

Across TCGA pan-cancer cohorts, H2AZP4 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of H2AZP4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where H2AZP4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H2AZP4 is over-expressed in tumor, although a few such as READ and KICH show the opposite, repressed pattern.

HNSC, UCEC, and COAD are the cancer types where H2AZP4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AZP4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.332	.001	8	view →
UCEC	All	III,IV	+0.747	.025	4	view →
COAD	All	All	+0.558	.001	4	view →
BRCA	All	All	+0.335	.001	4	view →
READ	All	III,IV	−0.295	.022	2	view →
KICH	All	All	−0.188	.005	2	view →
LIHC	All	All	+0.070	.014	2	view →
LUAD	Male	All	+0.576	.032	1	view →
BLCA	Female	IV	+0.513	.030	1	view →
READ	Female	All	+0.424	.048	1	view →
CHOL	All	All	+0.236	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 10 lineages.

H2AZP4–HNSC

Open the HNSC breakdown →