H2AZP2

Across TCGA pan-cancer cohorts, H2AZP2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated H2AZP2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H2AZP2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AZP2 expression acts as an unfavorable survival marker, although some lineages such as MESO and ACC show a favorable association.

HNSC, KIRC, and PRAD are the cancer types where H2AZP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.455	0.678	.008	34	view →
KIRC	DFS	Tertile	II,III,IV	0.413	0.615	.002	23	view →
PRAD	OS	Quartile	All	0.966	0.997	.008	22	view →
UVM	DFS	Median	III,IV	0.281	0.831	.005	20	view →
MESO	DFS	Quartile	IV	0.679	0.275	.009	18	view →
LUSC	OS	Median	III,IV	0.582	0.768	.007	17	view →
ACC	DFS	Median	III,IV	0.564	0.130	.002	15	view →
PAAD	DFS	Tertile	All	0.380	0.528	.014	12	view →
COAD	DFS	Median	All	0.834	0.725	.019	10	view →
ESCA	OS	Tertile	All	0.330	0.626	.014	9	view →
CESC	OS	Quartile	All	0.930	0.822	.026	6	view →
UCS	DFS	Median	All	0.152	0.392	.040	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

H2AZP2–HNSC (OS)

Open the HNSC breakdown →