H2AZ1

Across TCGA patient cohorts, H2AZ1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AZ1-associated genes across cancer lineages are ERK2, GAPDH, and GSK-3_pS9. Each is linked with H2AZ1 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AZ1-to-partner and partner-to-H2AZ1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by H2AZ1-low versus H2AZ1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AZ1→partner) and Y-score (partner→H2AZ1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.211	+3.169	.029	.019	3	1
UCEC	GAPDH →	+0.596	+3.459	.027	.005	3	1
UCEC	GSK-3_pS9 →	+0.434	+3.000	.032	.036	3	1
UCEC	Annexin-1 →	+0.785	+3.459	.002	.005	3	1
UCEC	STAT3_pY705 →	-0.348	-2.321	.008	.035	3	1
UCEC	ATM →	-0.726	-3.169	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ERK2 by H2AZ1 expression — UCEC

Explore this box plot interactively →