Across TCGA pan-cancer cohorts, H2AX Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated H2AX data layer compared with 30 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher H2AX Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2AX expression acts as an unfavorable survival marker.

LUAD are the cancer types where H2AX Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.090	0.709	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: H2AX tumor-vs-normal RNA expression · all H2AX data types