Across TCGA pan-cancer cohorts, H2AX mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H2AX data layer compared with 30 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher H2AX mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated H2AX expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where H2AX mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	1.000	0.600	<.001	26	view →
PDAC	DFS	Tertile	All	0.648	0.383	.010	12	view →
GBM	OS	Median	All	0.672	0.397	.003	10	view →
LSCC	OS	Median	All	0.928	0.805	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: H2AX tumor-vs-normal RNA expression · all H2AX data types