Across TCGA patient cohorts, H2AX protein abundance is significantly associated with the RNA expression of many other genes, with 8,364 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible H2AX-associated genes across cancer lineages are HINFP, TUBA1C, and ATM. Each is linked with H2AX in more than 4 cancer types. Because this analysis shows association rather than direction, both H2AX-to-partner and partner-to-H2AX results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AX→partner) and Y-score (partner→H2AX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	HINFP →	+0.470	+0.591	<.001	<.001	3	5
HNSC	TUBA1C →	-0.695	-0.333	.004	.002	3	5
HNSC	ATM →	+0.624	+0.557	<.001	<.001	3	4
CCRCC	PSME3 →	-0.406	-0.423	<.001	<.001	3	4
LSCC	PIAS3 →	-0.636	-0.328	<.001	.002	3	4
COAD	RAD9A →	+0.444	+0.724	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,364 associations by consensus.

Exploration

H2AX survival (RNA) · tumor vs normal (RNA) · all H2AX data types