Across TCGA pan-cancer cohorts, H2AC7 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated H2AC7 data layer compared with 25 for mass-spec protein.
The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher H2AC7 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC7 expression acts as an unfavorable survival marker.
BLCA, COAD, and OV are the cancer types where H2AC7 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.