Across TCGA cell cohorts, H2AC7 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible H2AC7-associated genes across cancer lineages are OR11H1, AKAP4, and OR4K2. Each is linked with H2AC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC7-to-partner and partner-to-H2AC7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC7→partner) and Y-score (partner→H2AC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR11H1 →	+0.097	+5.201	<.001	.006	3	2
LUNG_NSCLC_LUAD	AKAP4 →	+0.013	+4.544	<.001	.003	3	1
BLOOD_Leukemia	OR4K2 →	+0.042	+5.969	<.001	.001	3	1
BLOOD_Leukemia	PRORY →	+0.173	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR11G2 →	+0.392	+4.922	<.001	.009	3	1
BLOOD_Leukemia	OR11H2 →	+0.060	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

H2AC7 survival (RNA) · tumor vs normal (RNA) · all H2AC7 data types