H2AC5P

Across TCGA pan-cancer cohorts, H2AC5P RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated H2AC5P data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher H2AC5P RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated H2AC5P expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUAD show a favorable association.

DLBC, UCEC, and ACC are the cancer types where H2AC5P RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	All	1.000	0.621	.001	53	view →
UCEC	DFS	Median	All	0.559	0.711	<.001	36	view →
ACC	DFS	Quartile	All	0.154	0.565	.001	26	view →
COAD	DFS	Tertile	IV	0.171	0.565	.003	24	view →
LUAD	DFS	Quartile	II,III,IV	0.828	0.571	.002	22	view →
LIHC	DFS	Median	II,III,IV	0.513	0.363	.012	21	view →
LUSC	OS	Median	All	0.812	0.637	.012	20	view →
STAD	DFS	Tertile	III,IV	0.581	0.413	.015	18	view →
UVM	OS	Quartile	III,IV	0.476	0.868	.001	17	view →
READ	DFS	Tertile	IV	1.000	0.481	.029	12	view →
SKCM	DFS	Tertile	II,III,IV	0.330	0.191	.022	10	view →
PRAD	OS	Median	All	0.806	0.995	.008	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

H2AC5P–DLBC (DFS)

Open the DLBC breakdown →