H2AC4

Across TCGA patient cohorts, H2AC4 RNA expression is significantly associated with the protein abundance of many other proteins, with 21,040 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible H2AC4-associated proteins across cancer lineages are MCM2_S41, POLD1, and POLD2. Each is linked with H2AC4 in more than 7 cancer types. Because this analysis shows association rather than direction, both H2AC4-to-partner and partner-to-H2AC4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, H2AC4 versus MCM2_S41 in LUAD, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC4→partner) and Y-score (partner→H2AC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MCM2_S41 →	+0.879	+1.081	<.001	<.001	3	8
PDAC	POLD1 →	+0.379	+0.663	<.001	<.001	3	7
GBM	POLD2 →	+0.473	+1.472	<.001	<.001	3	7
UCEC	PRIM2 →	+0.443	+2.275	<.001	<.001	3	7
LUAD	RACGAP1 →	+0.857	+1.309	<.001	<.001	3	7
LUAD	RFC1_T506 →	+1.300	+1.442	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,040 associations by consensus.

H2AC4 vs MCM2_S41 — LUAD

Explore this scatter interactively →