H2AC4

Across TCGA patient cohorts, H2AC4 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AC4-associated genes across cancer lineages are RNU6-381P, RN7SL240P, and EIF1AY. Each is linked with H2AC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC4-to-partner and partner-to-H2AC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-381P grouped by H2AC4-low versus H2AC4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC4→partner) and Y-score (partner→H2AC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-381P →	+0.331	+8.471	<.001	.005	3	1
BRCA	RN7SL240P →	+0.143	+7.731	<.001	.009	3	1
UCEC	EIF1AY →	+0.040	+4.374	.001	.007	3	1
UCEC	RNA5SP393 →	+0.625	+4.936	<.001	.002	3	1
UCEC	TRAJ40 →	+1.130	+4.326	<.001	.007	3	1
UCEC	TRAJ24 →	+1.302	+4.326	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

RNU6-381P by H2AC4 expression — BRCA

Explore this box plot interactively →