Across TCGA pan-cancer cohorts, H2AC21 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated H2AC21 data layer compared with 23 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher H2AC21 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC21 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where H2AC21 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.646	0.882	.015	9	view →
LUAD	OS	Tertile	All	1.000	0.702	.009	6	view →
PDAC	OS	Tertile	All	0.702	0.446	.010	6	view →
CCRCC	DFS	Tertile	IV	1.000	0.213	.024	6	view →
UCEC	OS	Tertile	II,III,IV	0.644	1.000	.045	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: H2AC21 tumor-vs-normal RNA expression · all H2AC21 data types