Across TCGA pan-cancer cohorts, H2AC21 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of H2AC21’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where H2AC21 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types H2AC21 is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

PDAC, LUAD, and HNSC are the cancer types where H2AC21 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H2AC21 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	All	All	+0.902	<.001	7	view →
LUAD	Female	All	−0.228	.015	3	view →
HNSC	Male	All	+0.164	.033	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: H2AC21 RNA expression & survival · all H2AC21 data types