Across TCGA cell cohorts, H2AC20 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Myeloma shows the largest number of these associations.

The most reproducible H2AC20-associated genes across cancer lineages are HTR2A, MS4A14, and SPINK8. Each is linked with H2AC20 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC20-to-partner and partner-to-H2AC20 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC20→partner) and Y-score (partner→H2AC20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HTR2A →	+0.023	+4.029	.008	.009	3	2
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1
OESOPHAGUS	C2orf83 →	+0.020	+4.906	<.001	.006	3	1
BLOOD_Myeloma	GALNTL5 →	+0.033	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KCNA10 →	+0.013	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

H2AC20 survival (RNA) · tumor vs normal (RNA) · all H2AC20 data types