Across TCGA pan-cancer cohorts, H2AC18 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated H2AC18 data layer.
The strongest signal is observed in uveal melanoma (UVM), where higher H2AC18 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated H2AC18 expression acts as an unfavorable survival marker, although some lineages such as OV and LUAD show a favorable association.
UVM, DLBC, and KIRP are the cancer types where H2AC18 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.