H2AC16

Across TCGA patient cohorts, H2AC16 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AC16-associated genes across cancer lineages are RNU6-222P, RNU6-1077P, and SNRPGP8. Each is linked with H2AC16 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC16-to-partner and partner-to-H2AC16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-222P grouped by H2AC16-low versus H2AC16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC16→partner) and Y-score (partner→H2AC16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-222P →	+1.128	+4.809	<.001	.003	3	1
UCEC	RNU6-1077P →	+0.630	+4.188	.006	.009	3	1
UCEC	SNRPGP8 →	+0.252	+4.937	<.001	.005	3	1
UCEC	EIF3JP1 →	+0.329	+4.690	.001	.003	3	1
UCEC	RPS21P2 →	+0.526	+4.936	<.001	.002	3	1
UCEC	BRWD1P3 →	+0.309	+4.969	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

RNU6-222P by H2AC16 expression — UCEC

Explore this box plot interactively →