H2AC15

Across TCGA patient cohorts, H2AC15 RNA expression is significantly associated with the go_rna of many other GO terms, with 501 significant associations in total. SCLC shows the largest number of these associations.

The most reproducible H2AC15-associated GO terms across cancer lineages are Regulation of double-strand break repair via homologous recombination, Regulation of protein kinase A signaling, and Positive regulation of plasminogen activation. Each is linked with H2AC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC15-to-partner and partner-to-H2AC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair via homologous recombination grouped by H2AC15-low versus H2AC15-high in SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC15→partner) and Y-score (partner→H2AC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	Regulation of double-strand break repair via homologous recombination →	+0.073	+1.323	<.001	<.001	3	1
SCLC	Regulation of protein kinase A signaling →	-0.120	-0.987	<.001	.001	3	1
SCLC	Positive regulation of plasminogen activation →	-0.245	-1.064	<.001	.005	3	1
SCLC	Formation of extrachromosomal circular DNA →	+0.115	+0.935	<.001	.002	3	1
SCLC	Facultative heterochromatin formation →	+0.097	+1.100	<.001	<.001	3	1
SCLC	DNA repair-dependent chromatin remodeling →	+0.135	+1.585	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 501 associations by consensus.

Regulation of double-strand break repair via homologous recombination by H2AC15 expression — SCLC

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