H2AC14

Across TCGA patient cohorts, H2AC14 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H2AC14-associated genes across cancer lineages are SEC61GP1, MIR3135B, and RNA5SP492. Each is linked with H2AC14 in more than 1 cancer types. Because this analysis shows association rather than direction, both H2AC14-to-partner and partner-to-H2AC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEC61GP1 grouped by H2AC14-low versus H2AC14-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC14→partner) and Y-score (partner→H2AC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SEC61GP1 →	+0.406	+4.112	<.001	.004	3	2
BLCA	MIR3135B →	+0.497	+3.680	.004	.009	3	2
UCEC	RNA5SP492 →	+0.451	+3.525	<.001	.001	3	2
UCEC	LINC02536 →	+0.060	+3.997	.001	.009	3	1
UCEC	CFC1B →	+0.034	+4.292	<.001	.006	3	1
UCEC	FOXN3P1 →	+0.078	+2.867	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

SEC61GP1 by H2AC14 expression — BLCA

Explore this box plot interactively →