H2AC14

Across TCGA cell cohorts, H2AC14 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,943 significant associations in total. PANCREAS shows the largest number of these associations.

The most reproducible H2AC14-associated GO terms across cancer lineages are Positive regulation of DNA-templated DNA replication, Meiotic chromosome separation, and Regulation of nuclear division. Each is linked with H2AC14 in more than 7 cancer types. Because this analysis shows association rather than direction, both H2AC14-to-partner and partner-to-H2AC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated DNA replication grouped by H2AC14-low versus H2AC14-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (H2AC14→partner) and Y-score (partner→H2AC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of DNA-templated DNA replication →	+0.083	+0.792	.007	.006	3	8
LUNG_NSCLC_LUAD	Meiotic chromosome separation →	+0.146	+0.656	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of nuclear division →	+0.088	+0.714	.007	.007	3	7
PANCREAS	Regulation of mitotic nuclear division →	+0.061	+0.547	.005	.003	3	7
BREAST	Astrocyte activation →	-0.106	-0.553	.002	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	DNA replication initiation →	+0.135	+0.752	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,943 associations by consensus.

Positive regulation of DNA-templated DNA replication by H2AC14 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →