Across TCGA pan-cancer cohorts, H1-9P RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of H1-9P’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where H1-9P RNA is more highly expressed in tumor relative to normal tissue. In most cancer types H1-9P is over-expressed in tumor, although a few such as UCEC and COAD show the opposite, repressed pattern.
KIRC, UCEC, and COAD are the cancer types where H1-9P tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in H1-9P RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.