H1-8

Across TCGA pan-cancer cohorts, H1-8 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated H1-8 data layer compared with 13 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher H1-8 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated H1-8 expression acts as an unfavorable survival marker.

LUAD, UCEC, and SCLC are the cancer types where H1-8 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.004	0.835	<.001	25	view →
UCEC	OS	Median	IV	0.259	0.770	<.001	12	view →
SCLC	DFS	Median	All	0.192	0.793	.017	6	view →
COAD	DFS	Median	All	0.160	0.693	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

H1-8–LUAD (OS)

Open the LUAD breakdown →