Across TCGA pan-cancer cohorts, H1-5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated H1-5 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher H1-5 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated H1-5 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where H1-5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	IV	1.000	0.451	.016	13	view →
PDAC	OS	Median	II,III,IV	0.696	0.956	.009	8	view →
LUAD	OS	Quartile	III,IV	0.303	0.848	.005	7	view →
OV	DFS	Median	All	0.582	0.876	.037	4	view →
HNSC	DFS	Median	IV	0.924	1.000	.037	4	view →
UCEC	DFS	Median	All	1.000	0.937	.023	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: H1-5 tumor-vs-normal RNA expression · all H1-5 data types