Across TCGA patient cohorts, H1-5 mutation is significantly associated with the RNA expression of many other genes, with 719 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H1-5-associated genes across cancer lineages are RNU6-147P, IGFBP2, and KLRD1. Each is linked with H1-5 in more than 2 cancer types. Because this analysis shows association rather than direction, both H1-5-to-partner and partner-to-H1-5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H1-5→partner) and Y-score (partner→H1-5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-147P →	+0.229	+3.642	<.001	<.001	3	3
CESC	IGFBP2 →	-2.207	-3.575	<.001	.002	3	2
CESC	KLRD1 →	+0.725	+3.634	<.001	.001	3	2
CESC	CLEC12A →	+0.955	+3.321	<.001	.009	3	2
UCEC	TRBV10-1 →	+0.402	+2.451	<.001	.003	3	2
CESC	ERVMER34-1 →	-1.206	-3.307	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 719 associations by consensus.

Exploration

H1-5 survival (RNA) · tumor vs normal (RNA) · all H1-5 data types